She was active in the civic life of her country and held many honorary and active positions, including chairman of Fu Jen Catholic University.During the Second Sino-Japanese War she rallied her people against the Japanese invasion and in 1942 conducted a speaking tour of the United States to gain support.
In 1908, Ching-ling was accepted by her sister Ai-ling's alma mater, Wesleyan College, at age 15 and both sisters moved to Macon, Georgia, to join Ai-ling.
However, she could not get permission to stay on campus as a family member nor could she be a student because she was too young.
In order to better provide for these children she established the Chinese Women's National War Relief Society.
After losing to President Franklin Roosevelt in the 1940 US election, Republican candidate Wendell Willkie set out to travel the world in service to the US.
In 1931, Soong Mei-ling had a villa built for her on the east side of Nanjing.
Located a few hundred meters east of the Sifangcheng Pavilion of the Ming Xiaoling Mausoleum, the villa still exists, and is commonly known as Meilinggong (美龄宫), "May-ling Palace".
She referred to these children as her "warphans" and made them a personal cause.
The fate of the children of fallen soldiers became a much more important issue in China after the beginning of the war with Japan in 1937.
Their father, who had studied in the United States, arranged to have them continue their education in the US in 1907.